Cortexin
What is Cortexin?
Cortexin is a complex of water-soluble polypeptide fractions extracted from the cerebral cortex of young cattle, with molecular weights ranging from 1,000 to 10,000 Daltons. These low-molecular-weight neuropeptides are capable of crossing the blood-brain barrier and exerting tissue-specific effects on the cerebral cortex. The peptide complex modulates neuronal metabolism, regulates neurotransmitter balance (particularly serotonin, dopamine, and amino acids), and restores bioelectrical activity in the brain. Cortexin has been extensively studied in Russia for over 20 years and is used clinically for various neurological and neurodevelopmental conditions.
Mechanism of Action
Regulates the ratio of inhibitory (GABA) and excitatory (glutamate, aspartate) amino acids, normalizes levels of serotonin and dopamine, enhances cerebral metabolism, and restores bioelectrical activity of the brain through direct action on cortical neurons.
Benefits
- Improves higher cerebral functions (memory, attention, learning)
- Neuroprotection against oxidative stress, hypoxia, and neurotoxins
- Accelerates recovery after stroke, TBI, and neurosurgery
- Reduces cognitive decline in neurodegenerative conditions
Clinical Applications
Typical Dosage
- 10mg intramuscularly daily for 10 days (injectable form only - no capsule formulation available)
Side Effects
While generally considered safe when used correctly, potential side effects should be monitored. Discontinue use if adverse reactions occur.