Dihexa

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a small molecular weight oligopeptide derived from angiotensin IV, designed as a potent cognitive enhancer and neurogenic agent. It is considered one of the most powerful nootropic compounds ever developed, showing remarkable ability to promote synaptogenesis (formation of new synapses), enhance neurite outgrowth, and facilitate neuronal repair. Dihexa crosses the blood-brain barrier efficiently and has demonstrated extraordinary improvements in cognitive function, memory consolidation, and learning capacity in preclinical models. It works through the hepatocyte growth factor (HGF) and its receptor c-Met, promoting neuroplasticity and neuronal survival. Dihexa has shown promise in treating Alzheimer disease, traumatic brain injury, stroke recovery, and age-related cognitive decline.

Dihexa functions as an HGF/c-Met pathway agonist, binding to and activating the hepatocyte growth factor receptor (c-Met) in the brain. This activation triggers a cascade of intracellular signaling pathways including PI3K/Akt and MAPK/ERK that promote neuronal survival, neurite outgrowth, and synaptogenesis. Unlike traditional nootropics that merely enhance neurotransmitter activity, Dihexa actually creates new neuronal connections and repairs damaged brain circuits. It increases synaptic density in the hippocampus and cortex, enhances dendritic branching, and upregulates brain-derived neurotrophic factor (BDNF) expression. The compound also protects neurons from excitotoxicity and oxidative stress while promoting neurogenesis in key brain regions involved in learning and memory.