AppetiteFat LossMetabolismCardiovascular

Semaglutide

What is Semaglutide?

Semaglutide is a GLP-1 receptor agonist that mimics the action of the human glucagon-like peptide-1 (GLP-1). It increases insulin secretion, decreases glucagon secretion, and slows gastric emptying.

Mechanism of Action

Acts on GLP-1 receptors in the brain to regulate appetite and food intake. It also enhances glucose-dependent insulin secretion from the pancreas.

Benefits

  • Significant weight loss
  • Improved blood sugar control
  • Reduced appetite and cravings
  • Cardiovascular benefits
  • Potential neuroprotective effects

Typical Dosage

  • 0.25mg weekly, titrating up to 2.4mg weekly

Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Fatigue

Dosage Protocol

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist with a prolonged half-life of approximately 7 days. This educational protocol presents a gradual weekly titration from 0.25 mg up to a maintenance dose of 2.4 mg over 16+ weeks. Weekly dose range: 250–2400 mcg (0.25–2.4 mg) once weekly.

Reconstitution

Reconstitute with 3.0 mL bacteriostatic water → ~3.33 mg/mL concentration. 1. Draw 3.0 mL bacteriostatic water with a sterile syringe. 2. Inject slowly down the vial wall to minimize foaming; avoid shaking. 3. Gently swirl or roll the vial until the powder is fully dissolved. 4. Label the vial with the reconstitution date and refrigerate at 2–8 °C (35.6–46.4 °F), protected from light. 5. Use reconstituted solution within 28 days.

Dosing Schedule

Standard Protocol

  • •Frequency: Inject once weekly subcutaneously
  • •Timing: Administer on the same day each week
  • •Titration: Gradual increase from 0.25mg to 2.4mg over 16+ weeks

Negative Interactions

  • Alcohol
  • High-fat meals
  • Other GLP-1 medications

This guide is for educational purposes only. Always consult with a qualified healthcare professional.

HomeLibraryResearchFavoritesToolsVisuals