MetabolismNAD+ ModulatorFat LossEnergyAnti-aging

5-Amino-1MQ

What is 5-Amino-1MQ?

5-Amino-1MQ is a small molecule inhibitor of the enzyme NNMT (Nicotinamide N-methyltransferase). By blocking NNMT, it increases NAD+ levels and metabolic rate, making it a potent agent for fat loss and longevity.

Mechanism of Action

It inhibits NNMT, an enzyme that consumes NAD+ and is upregulated in fat tissue. Inhibition leads to higher NAD+ levels, increased sirtuin activity, and enhanced metabolic rate without stimulating the nervous system.

Benefits

  • Significant fat loss (white adipose tissue)
  • Increases cellular NAD+ levels
  • Improves muscle function and recovery
  • No stimulant effects (jitters/heart rate)
  • Potential anti-aging properties

Typical Dosage

  • Oral: 50-100mg daily
  • Injectable: 150mcg-600mcg daily
  • 4-8 week cycles with 2-4 week breaks

Side Effects

  • Minimal reported side effects
  • Potential for mild insomnia if taken late

Negative Interactions

  • High-carb meals (may reduce effectiveness)
  • NAD+ depleting substances
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