5-Amino-1MQ

5-amino-1MQ (5-amino-1-methylquinolinium) is a small molecule that inhibits nicotinamide N-methyltransferase (NNMT), an enzyme that depletes cellular NAD+ stores. By blocking NNMT, 5-amino-1MQ prevents NAD+ breakdown, leading to higher intracellular NAD+ availability. This increase fuels mitochondrial function, DNA repair, and cellular resilience. The elevation of NAD+ triggers a metabolic shift towards greater energy expenditure and enhanced fatty acid oxidation, meaning the body burns more calories and fat. It can also activate the SIRT1 gene, associated with improved metabolic health and anti-aging effects. Unlike many weight loss methods, it helps maintain lean muscle mass while shedding fat.