AI & Developer Access

The Bioregulator Atlas is published by Kymata Labs LLC. Reference site on peptide bioregulators: the Khavinson Cytomax and Cytogen compounds, the Vita Peptides house line, the published studies behind them and organ-system stacks, with honest evidence notes.

Most bioregulator research comes from one Russian research program, often on injected extracts, cell cultures or animals. No human trial has tested a specific Vita Peptides product. Supplement pages use structure/function wording; nothing on the site is intended to diagnose, treat, cure or prevent any disease, and nothing replaces advice from a clinician.

Injectable research peptides (BPC-157, TB-500, GLP-1 drugs, GH secretagogues) and dosing math are covered on our companion site, CalcMyPeptide; the Atlas links there instead of duplicating them.

All files are generated at build time from the same data as the pages. They list only indexable URLs (no redirects, no noindexed pages).

/robots.txt

Crawl policy: all search and AI crawlers allowed; only /api/ is disallowed. Points to the sitemap.

/sitemap.xml

Every indexable 200 URL with the date its source last changed. Redirected and noindexed URLs are excluded.

/sitemap-images.xml

Article cover images and infographics on indexable pages.

/llms.txt

Compact guide for language models: what the site covers, key pages, guides, products and data.

/llms-full.txt

Extended text: every bioregulator, Vita Peptides product, study and guide with a one-line summary and URL.

/feed.json

JSON Feed 1.1 of research articles and guides, newest first.

/schema-feed.json

schema.org DataFeed (JSON-LD) of articles, product guides, compound pages and the evidence dataset.

/.well-known/ai.json

AI discovery manifest: site identity, counts, key URLs, policies, disclosure and citation format. Also served at /ai.json.

/.well-known/nlweb.json

NLWeb discovery: where the schema feed, sitemap and llms files are. There is no live query endpoint.

/.well-known/agent-card.json

Agent card describing the read-only skills an agent can use (look up a compound, product, study, evidence row).

/.well-known/ai-plugin.json

Plugin-style manifest pointing to openapi.yaml.

/openapi.yaml

OpenAPI 3.0.3 description of the static, read-only files above (no compute API). Also at /.well-known/openapi.yaml.

/rsl.json

Content licensing terms (RSL).

/data/bioregulator-evidence-index.csv

One row per compound: PubMed records, human records, trials, RCTs and first/latest year (PubMed E-utilities, 2026-10-06).

• Home: Overview of peptide bioregulators and entry points to the catalog, Vita Peptides line, studies and stacks.
• Khavinson bioregulator catalog: Every Cytomax and Cytogen compound by organ system, with mechanism notes and label dosing.
• What are peptide bioregulators?: Definitions, proposed mechanism and what the evidence does and does not show.
• Cytomax vs Cytogen: Natural tissue-extract peptides versus synthesized short peptides.
• Prof. Vladimir Khavinson: Biography of the researcher behind peptide bioregulators.
• Bioregulator Evidence Index: PubMed record counts, human-trial records and first study year per compound, with queries and a CSV.
• Health hubs: Goal-based hubs linking bioregulator research to buyable products and prescription options, with evidence notes and checked prices.
• Longevity & healthy aging hub: Bioregulators (Epitalon, Epithalamin, Vita Defender), NAD+ and sermorelin via licensed telehealth: evidence, FDA status and prices.
• Women's health & hormones hub: Menopause and perimenopause HRT (incl. Duavee $30.30 on TrumpRx), online HRT, Natural Cycles, and what ovarian bioregulators can and cannot do.
• Sleep, stress & cognition hub: CBT-I first; what Pinealon, Epitalon and pineal/brain bioregulator research shows; capsules sold by Vita-Stream.
• Immune support hub: Sleep, vitamin D and vaccination basics first; what the Thymalin (injectable thymus extract) studies do and do not show; thymus bioregulator capsules sold by Vita-Stream.
• Joints, bones & mobility hub: Exercise first (Cochrane, ACR 2019, LIFTMOR); the thin cartilage-bioregulator evidence (one uncontrolled Sigumir study); Cartesyl, Collacell, Sigumir and Cartalax capsules.
• Gut & digestive health hub: When digestive symptoms need a clinician (ACG guidelines), and what stomach, gastric-mucin, liver and pancreas bioregulators (Stomek, Gastrogen, Liverra, Vita Detox, Stamakort, Suprefort) have behind them: animal and lab work only.
• Heart & vascular health hub: AHA Life's Essential 8 first; what heart and blood-vessel bioregulators (Kardium, Chelohart, Ventfort, Vesugen) have behind them: lab work on vascular cells and one small uncontrolled Vesugen study.
• Eyes & vision hub: Regular eye exams and the AREDS2 trial results first; what Retinalamin (injectable retinal peptides, Russian clinical studies) does and does not show; Visoluten retina capsules.
• Men's health hub: How low testosterone is diagnosed (AUA and Endocrine Society 2018), what TRAVERSE found, and what prostate and testes bioregulators (Vita Man, Prostalon, Testovive, Libidon, Testoluten) do and do not have behind them.
• Comparison guides: Epitalon vs Epithalamin, bioregulators vs peptides, Thymalin vs thymosin alpha-1: human and lab evidence kept apart, PubMed-linked.
• Epitalon vs Epithalamin: Epithalamin is an injectable pineal extract; Epitalon (AEDG) is the synthetic tetrapeptide modeled on it. Human data (melatonin rhythm, one long-term observational study) are on Epithalamin; telomere data on Epitalon are from cells. Neither is sold by Vita-Stream; Endoluten is the closest oral capsule.
• Bioregulators vs peptides: Peptide bioregulators (2–4 amino-acid Cytogens and tissue-extract Cytomax capsules) vs approved peptide drugs (semaglutide: large RCTs) vs gray-market research peptides (BPC-157: FDA has limited or no safety information). Evidence, legal status and route compared.
• Thymalin vs thymosin alpha-1: Thymalin is a Russian injectable thymus polypeptide extract (human data mostly from the originating group); thymosin alpha-1 is a single 28-amino-acid peptide studied in randomized trials (Cochrane 2026, hepatitis B: very low-certainty evidence). Neither is FDA-approved; oral thymus capsules are a third, untested option.
• NMN vs NR vs NAD+: NMN and NR both raise blood NAD+ in people (2026 randomized study of 65 adults: comparable rise; nicotinamide did not). Health outcomes are mixed and often null (2026 systematic review of 33 human studies). No outcome trial of IV or injected NAD+. Since Sept 29, 2025 the FDA says NMN is not excluded from the US dietary supplement definition.
• Urolithin A: Urolithin A: lifespan in worms and muscle function in rodents; in people, safe and active on mitochondrial biomarkers, improved muscle endurance (older adults) and strength (~12%, middle-aged) but missed several primary endpoints. 2025 immune trial: more naive-like CD8 T cells. Most trials funded by the maker of Mitopure.
• Rapamycin for longevity: Rapamycin (sirolimus): FDA-approved for kidney transplant rejection prophylaxis and LAM, with a boxed immunosuppression warning; anti-aging use is off-label. Extended mouse lifespan (2009). Humans: mTOR inhibitors improved flu-vaccine response and cut reported infections in older adults; PEARL (48 weeks, 5 or 10 mg weekly) missed its primary endpoint but was relatively safe.
• Spermidine: Spermidine: extends lifespan in yeast, flies, worms and mice; higher dietary intake linked to lower mortality in an observational cohort (HR 0.74 per SD). In people, a 3-month pilot suggested a memory benefit but the 12-month SmartAge RCT (0.9 mg/day) found no effect on memory or biomarkers.
• Taurine and aging: Taurine: 2023 Science paper reported blood taurine falls with age and supplementation extended healthspan/lifespan in mice and healthspan in monkeys; a 2025 Science paper found taurine rose or stayed flat with age in three human cohorts. Human data: one small 16-week trial on antioxidant markers. No human trial on aging outcomes.
• Creatine for the brain: Creatine and cognition: 2023 meta-analysis of 8 RCTs found a small memory benefit overall (SMD 0.29), larger in adults 66–76 (SMD 0.88), none in younger people. A single high dose improved performance during sleep deprivation in a lab study. ISSN: safe in healthy people.
• Magnesium for sleep: Magnesium for sleep: meta-analysis of 3 RCTs in 151 older adults found 17 minutes faster sleep onset, no significant change in total sleep, low-quality evidence. Magnesium L-threonate improved Oura-measured deep/REM scores in one 21-day industry-linked trial. NIH upper limit for supplemental magnesium: 350 mg/day for adults.
• Melatonin for older adults: Melatonin: meta-analysis of 19 trials (1,683 people): 7 min faster sleep onset, 8 min more sleep. In adults over 50 with insomnia, 0.3 mg restored sleep efficiency; 3 mg left daytime levels raised. Prolonged-release 2 mg in ages 55–80: responders 26% vs 15%. AASM does not recommend it for chronic insomnia; supplement labels are often inaccurate.
• Protocols: In-depth protocols for specific health goals, including the Ultimate Athletic Performance Stack.
• Ultimate athletic peptide stack: Stacking for athletic performance and recovery: the peptides and bioregulators involved, phasing, and the research behind them.
• The Spartan Protocol: Educational case study: a needle-free bioregulator stack (Endoluten, Thyrix, Sport 5 Plus) with protein, hydration and training under a low lifting limit.
• Research tools & calculators: Reconstitution calculator, cycle planner, injection guide and bioregulator body map.
• Peptide cycle planner: Lay out a peptide or bioregulator protocol on a schedule, with dose math and a shopping list.
• Bioregulator body map: Interactive anatomical guide: the Khavinson bioregulator for each organ system.
• Peptide injection guide: Visual guide to SubQ and IM injection technique, site selection and safety.
• Peptide & bioregulator library: Catalog of Khavinson bioregulators and modern peptides, filterable by organ system, generation and benefit.
• Infographics: Visual references: safety pyramid, periodic table, synergy wheel, peptide scale and downloadable infographics.
• Infographic downloads: Printable infographics: mitochondrial optimizers, tissue-repair timelines, growth hormone patterns, GLP-1 mechanisms, nootropic pathways.
• Peptides vs bioregulators scale: The spectrum from gentle bioregulators to potent synthetic peptides.
• Periodic table of peptides: Compounds organized by class, potency and mechanism of action.
• Peptide safety pyramid: Safety profiles compared across bioregulators, peptides and hormones.
• Synergy wheel: Common peptide pairings and how the compounds relate.
• Stack finder quiz: Five questions suggest a 1–3 product bioregulator stack with label notes and course prices.
• Vita Peptides line: All Vita Peptides single-tissue bioregulators and complexes with tissue, dosing and price.
• Bioregulator stacks: Organ-system stacks (cardiovascular, brain, eye, immune and more).
• Study library: PubMed-backed summaries of bioregulator studies, with limitations.
• Bioregulator peptides and epigenetics: long-form review: Long-form review of bioregulator history, mechanism claims and evidence quality.
• The science: Background reading hub: gene expression, the research record, evidence index.
• How bioregulators may influence gene expression: The proposed mechanism and its limits.
• Bioregulator efficacy: what the research shows: The research record in context.
• Research library: All research articles and guides.
• Bioregulators and mental health research: Khavinson-group research on bioregulators and mental health.
• Safety profiles and precautions: General safety notes and who should be cautious.
• FAQ: Common questions about bioregulators.
• Peptide database: Index of research peptides; injectable peptides are covered in depth on CalcMyPeptide.
• About: Publisher, editorial approach and affiliate disclosure.
• AI & developer access: This list of machine-readable files, structured data and crawl policy.

Guides

• Huberman and Pinealon: What the Evidence Actually Says
• Pinealon vs. Natural (Cytomax) Bioregulators: What's the Difference?
• Epitalon Alternatives: Honest Options in 2026
• Thymalin vs. Thymus Bioregulators (Vladonix, Thymusol): Which Is Which?
• Khavinson Bioregulators Explained: A Beginner's Protocol
• How to Cycle Bioregulators: Course Length, Breaks and Bottle Math
• Best Bioregulator Stack for Longevity (Honest 2026 Version)
• Bioregulators for Women: A Practical, Honest Guide
• Bioregulators for Men Over 50: What to Take and What to Skip
• Vita Peptides vs. Other Bioregulator Brands: An Honest Comparison

Every compound, product, study and stack URL is listed in llms-full.txt and the sitemap.

• CalcMyPeptide peptide library: Injectable research peptides (BPC-157, TB-500, GLP-1s, GH secretagogues) with dosing math.
• Reconstitution calculator: Vial mg, water mL and syringe units.
• Khavinson peptides mapped (CalcMyPeptide): Dosing and unit pages for each Khavinson compound.
• CalcMyPeptide protocols: Goal and advanced stacking protocols with dosing math.
• CalcMyPeptide AI page: Machine-readable files for the companion site.

• WebSite, Organization: every page (site-wide)
• BreadcrumbList: every page below the homepage
• Article: /research/<slug> articles and guides
• ScholarlyArticle: /studies/<id> (PubMed record as sameAs)
• Dataset: /evidence-index
• FAQPage: /bioregulators/<id> and /vita/<slug>
• WebPage: homepage

Search and AI crawlers are allowed to crawl and index public pages; only /api/ is disallowed. Named in robots.txt: Googlebot, Google-Extended, Bingbot, Applebot, GPTBot, OAI-SearchBot, ChatGPT-User, ClaudeBot, Claude-SearchBot, PerplexityBot, Amazonbot, Meta-ExternalAgent, cohere-ai, CCBot, GrokBot and others.

Reuse and licensing terms are in rsl.json and the terms. There are no accounts and no public compute API; the OpenAPI file describes the static files and pages above.

Some pages link to Vita-Stream (vita-stream.com) with an affiliate code. The Bioregulator Atlas earns a commission on qualifying purchases at no extra cost to the buyer. Those links carry rel="sponsored" and a disclosure next to them. Shoppers can also enter the referral code KymataLabs at Vita-Stream checkout, which credits the order to the same affiliate account (any discount is set by Vita-Stream).

Cite the canonical URL of the specific page you used, for example:

The Bioregulator Atlas, "Bioregulator Evidence Index", https://www.thebioregulatoratlas.com/evidence-index

Corrections: contact page.