Bioregulator Evidence Index
Data retrieved from PubMed on 2026-10-06. 41 compounds. Original dataset by The Bioregulator Atlas.
The short answer
Of 41 peptide bioregulators we track, 21 have at least one PubMed record under their own name, and only 10 have a record indexed as a human clinical trial (69 trial records out of 896 records in total). 20 have no PubMed record at all, including 18 brand-name natural (Cytomax) capsule products. Most of the human research that does exist was done on injectable preparations by Russian research groups.
Key findings
- The most-published compounds are Thymalin (245 records), Cortexin (207 records), Epitalon (145 records). Thymalin and Cortexin are registered injectable medicines in Russia, which is where most of their trial records come from.
- Epitalon has 145 PubMed records but 1 indexed as a human clinical trial. Most Epitalon work is cell and animal research.
- Pinealon, the compound behind the 2026 sleep-podcast interest, has 18 PubMed records and 1 indexed human clinical trial.
- Brand-name capsules such as Vladonix, Endoluten and Cerluten return zero PubMed records under their own names. Research quoted for them was done on related extracts, which is not the same as evidence for the capsule.
- A count measures how much has been published, not whether a compound works or is safe.
The index
Download CSV| Compound | Type | Target | PubMed records | Human-indexed | Human trials | RCTs | First record | First human trial | Latest record | Query |
|---|---|---|---|---|---|---|---|---|---|---|
| Thymalin | Cytomax | Thymus | 245 | 165 | 12 | 1 | 1981 | 1982 | 2024 | PubMed |
| Cortexin | Cytomax | Brain | 207 | 142 | 34 | 17 | 1980 | 1994 | 2026 | PubMed |
| Epitalon | Cytogen | Pineal Gland | 145 | 47 | 1 | 0 | 1993 | 2002 | 2026 | PubMed |
| Epithalamin | Cytomax | Pineal Gland | 88 | 38 | 7 | 6 | 1977 | 1979 | 2025 | PubMed |
| Vilon | Cytogen | Thymus | 62 | 20 | 3 | 1 | 1997 | 2005 | 2023 | PubMed |
| Prostatilen | Cytomax | Prostate | 28 | 18 | 5 | 2 | 1991 | 1991 | 2026 | PubMed |
| Retinalamin | Cytomax | Retina | 25 | 20 | 4 | 3 | 2001 | 2006 | 2025 | PubMed |
| Cardiogen | Cytogen | Heart | 20 | 12 | 0 | 0 | 2006 | – | 2025 | PubMed |
| Livagen | Cytogen | Liver | 19 | 14 | 0 | 0 | 2001 | – | 2023 | PubMed |
| Pinealon | Cytogen | Brain | 18 | 10 | 1 | 0 | 2008 | 2012 | 2026 | PubMed |
| Vesugen | Cytogen | Blood Vessels | 11 | 7 | 0 | 0 | 2008 | – | 2021 | PubMed |
| Bronchogen | Cytogen | Bronchi | 7 | 2 | 0 | 0 | 2006 | – | 2017 | PubMed |
| Pancragen | Cytogen | Pancreas | 7 | 3 | 0 | 0 | 2006 | – | 2015 | PubMed |
| Sigumir | Cytomax | Cartilage | 3 | 3 | 1 | 0 | 2012 | 2012 | 2023 | PubMed |
| Samprost | Cytomax | Bladder | 3 | 1 | 0 | 0 | 2011 | – | 2025 | PubMed |
| Chitomur | Cytomax | Bladder | 2 | 1 | 1 | 1 | 2013 | 2013 | 2013 | PubMed |
| Testagen | Cytogen | Testes | 2 | 1 | 0 | 0 | 2011 | – | 2025 | PubMed |
| Cartalax | Cytogen | Cartilage | 1 | 1 | 0 | 0 | 2023 | – | 2023 | PubMed |
| Chelohart | Cytomax | Heart | 1 | 0 | 0 | 0 | 2015 | – | 2015 | PubMed |
| Chonluten | Cytogen | Lungs | 1 | 1 | 0 | 0 | 2022 | – | 2022 | PubMed |
| Crystagen | Cytogen | Thymus | 1 | 0 | 0 | 0 | 2014 | – | 2014 | PubMed |
| Bonomarlot | Cytomax | Bone Marrow | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Bonothyrk | Cytomax | Parathyroid | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Cerluten | Cytomax | Brain | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Endoluten | Cytomax | Pineal Gland | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Glandokort | Cytomax | Adrenal Glands | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Gotratix | Cytomax | Muscle | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Libidon | Cytomax | Prostate | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Normoftal | Cytogen | Eye | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| OvagenName collision: "Ovagen" is also a veterinary FSH product; query restricted to peptide/bioregulator context. | Cytogen | Liver | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Pielotax | Cytomax | Kidneys | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Stamakort | Cytomax | Stomach | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Suprefort | Cytomax | Pancreas | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Svetinorm | Cytomax | Liver | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Taxorest | Cytomax | Lungs | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Testoluten | Cytomax | Testes | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Thyreogen | Cytomax | Thyroid | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Ventfort | Cytomax | Blood Vessels | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Visoluten | Cytomax | Eye | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Vladonix | Cytomax | Thymus | 0 | 0 | 0 | 0 | – | – | – | PubMed |
| Zhenoluten | Cytomax | Ovaries | 0 | 0 | 0 | 0 | – | – | – | PubMed |
How the numbers were made
- For each compound we searched PubMed (NCBI E-utilities, esearch) for its name and common spellings in titles and abstracts. Where a well-defined amino-acid sequence name is widely used (for example Ala-Glu-Asp-Gly for Epitalon) it is included. The exact query for every row is linked in the table and included in the CSV.
- Human-indexed adds the MeSH term Humans. Human trials adds:
(humans[mh] AND (clinical trial[pt] OR randomized controlled trial[pt] OR controlled clinical trial[pt] OR clinical study[pt])). RCTs uses the Randomized Controlled Trial publication type alone. - First record is the earliest publication year among matching records that also match
(peptid*[tiab] OR polypeptid*[tiab] OR bioregulat*[tiab] OR Khavinson V[au] OR Khavinson VKh[au]), which removes older papers where the same word means something else. - Duplicate spellings are merged (Kartalax into Cartalax, Honluten into Chonluten). Multi-ingredient complexes are not included.
Limits
- PubMed indexes only part of the Russian-language literature, so these counts understate the total published record. They do reflect what most English-language readers, clinicians and AI search tools can find.
- Publication-type tags are often missing on older papers, so some human studies are not counted as trials, and a tagged trial can still be small or uncontrolled.
- A name match is not a study of the product sold under that name. Most human records concern injectable extracts, not oral capsules.
- Name collisions are possible; known ones are noted in the table.
Use and citation
The data are free to reuse with a link to this page. Cite as: The Bioregulator Atlas, “Bioregulator Evidence Index” (2026-10-06), https://www.thebioregulatoratlas.com/evidence-index.
For what each study actually found, open the compound's page or the study library. For background, read what bioregulators are.
Educational information only, not medical advice. Statements about dietary supplements have not been evaluated by the FDA. This site earns affiliate commissions on some product pages; this data page contains no product links.