Scientific ResearchKhavinson Protocol
Explore 40+ years of research from the St. Petersburg Institute, including studies on cosmonauts, Olympic athletes, and longevity.
Application of bioregulating therapy in complex treatment of temporomandibular joint diseases in people of elderly and senile age
Russian observational report on 62 older patients with jaw-joint (TMJ) problems who received the cartilage/bone peptide complex Sigumir as part of multi-part care.
Key Findings
- •Observational report
- •Combined-care design
Cortexin in the complex treatment of post stroke epilepsy
Small Russian-language clinical report: 29 of 46 patients on standard care also received injected Cortexin for 15 days; the authors report better EEG changes in that group.
Key Findings
- •Small comparative clinical report
- •EEG used as the outcome
Peptides of pineal gland and thymus prolong human life
Observational follow-up of 266 older adults for 6-8 years: the authors report lower mortality in groups given injected Thymalin and/or Epithalamin than in controls.
Key Findings
- •Lower reported mortality in treated groups
- •Lower reported respiratory illness incidence
Peptide Epitalon activates chromatin at the old age
Cell-culture study: synthetic Epitalon activated ribosomal genes and loosened condensed heterochromatin in cultured lymphocytes from people aged 76-80.
Key Findings
- •Chromatin activation in aged cells
- •Ribosomal gene activity increased
Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Cell-culture study: adding Epitalon (Epithalon) to telomerase-negative human fetal fibroblasts induced telomerase expression and activity and telomere elongation.
Key Findings
- •Telomerase catalytic subunit expression induced in fetal fibroblast cultures
- •Telomerase activity induced
Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa
Rat and small clinical study on retinal degeneration: Epitalon preserved retinal structure and function in Campbell rats; the authors report a positive clinical effect in most treated patients.
Key Findings
- •Retinal function preserved in an animal model
- •Small uncontrolled clinical series
Geroprotective effect of thymalin and epithalamin
Russian-language report of the same 266-person, 6-8 year follow-up: lower mortality reported in groups given injected Thymalin and/or Epithalamin versus controls.
Key Findings
- •Lower reported mortality in treated groups
- •Duplicate publication of one cohort
Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals
Review of the authors' own data: in aged rats Epithalamin lowered serum peroxidation markers and raised total antioxidant activity; fly data showed similar antioxidant effects.
Key Findings
- •Age-related changes in free-radical markers
- •Epithalamin lowered lipid peroxidation in animals
Effect of epitalon on the lifespan increase in Drosophila melanogaster
Fruit-fly study: synthetic Epitalon added only during development raised adult lifespan by 11-16% at very low concentrations, independent of dose.
Key Findings
- •Lifespan extension in fruit flies
- •Active at very low concentrations
Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats
Animal study: Epithalamin increased mean lifespan of female fruit flies, two mouse strains and rats by 11-31% and lowered mortality rate in flies, C3H/Sn mice and rats.
Key Findings
- •Lifespan extension in three animal species
- •Lower mortality rate in most models
Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster
Fruit-fly study comparing melatonin and the pineal extract Epithalamin added to larval food: Epithalamin increased mean life span in female flies (not males) and lowered lipid-peroxidation markers.
Key Findings
- •17% increase in mean life span in female flies
- •No effect in males or with melatonin