Scientific ResearchKhavinson Protocol
Explore 40+ years of research from the St. Petersburg Institute, including studies on cosmonauts, Olympic athletes, and longevity.
Suprefort Improves Glycemic Control in Type 2 Diabetes: A Pilot Study
Pilot study showing Suprefort improves HbA1c, insulin sensitivity, and beta-cell function in Type 2 diabetes patients.
Key Findings
- •Significant HbA1c reduction
- •Improved insulin sensitivity
Bronchogen in Chronic Obstructive Pulmonary Disease: A Controlled Study
Clinical trial demonstrating Bronchogen improves lung function, reduces exacerbations, and enhances quality of life in COPD patients.
Key Findings
- •Significant lung function improvement
- •Dramatic reduction in exacerbations (58%)
Cardiogen Improves Exercise Tolerance and Cardiac Function in Heart Failure Patients
Clinical study showing Cardiogen improves exercise capacity, LVEF, and quality of life in patients with chronic heart failure.
Key Findings
- •Major improvement in exercise capacity
- •Increased cardiac ejection fraction
Cerebrolysin Improves Cognitive Recovery After Stroke: Randomized Controlled Trial
Multicenter RCT demonstrating Cerebrolysin significantly improves cognitive function and reduces disability in post-stroke patients.
Key Findings
- •Dramatic cognitive improvement (2.8x better than placebo)
- •Enhanced functional independence
Hepatogen in Non-Alcoholic Fatty Liver Disease: A Controlled Clinical Trial
Clinical trial demonstrating Hepatogen reduces liver enzymes, improves liver steatosis on ultrasound, and decreases inflammation in NAFLD patients.
Key Findings
- •Liver enzyme normalization
- •Significant reduction in hepatic steatosis
Application of Bioregulating Therapy in Complex Treatment of Temporomandibular Joint Diseases
Clinical study demonstrating Sigumir improves joint mobility and reduces pain in elderly patients with TMJ osteoarthritis.
Key Findings
- •Effective pain reduction in TMJ osteoarthritis
- •Improved joint mobility and function
Glandokort in the Management of Chronic Fatigue and Adrenal Dysfunction
Observational study on the use of adrenal peptides (Glandokort) in patients with chronic fatigue syndrome, showing improved cortisol regulation and energy levels.
Key Findings
- •Normalized cortisol levels
- •Reduced fatigue symptoms
Ventfort Improves Endothelial Function and Reduces Blood Pressure in Hypertensive Patients
Clinical study showing Ventfort improves vascular endothelial function, reduces arterial stiffness, and lowers blood pressure in patients with essential hypertension.
Key Findings
- •Dramatic improvement in endothelial function
- •Reduced arterial stiffness
Retinalamin in the Treatment of Primary Open-Angle Glaucoma
Clinical study evaluating the neuroprotective effects of Retinalamin in patients with primary open-angle glaucoma.
Key Findings
- •Expansion of visual fields
- •Improved optic nerve conductivity
Neuroprotective Effects of Cortexin in Acute Ischemic Stroke Rehabilitation
Clinical trial showing that Cortexin administration in the acute phase of ischemic stroke accelerates neurological recovery, reduces infarct volume, and improves cognitive outcomes.
Key Findings
- •Faster improvement in NIHSS stroke scores
- •Better cognitive preservation post-stroke
Cardiogen Improves Myocardial Function in Patients with Coronary Heart Disease
Study showing that Cardiogen enhances myocardial contractility and exercise tolerance in patients with ischemic heart disease.
Key Findings
- •Increased heart ejection fraction
- •Reduced angina
Prostatilen in Chronic Prostatitis: Double-Blind Placebo-Controlled Study
High-quality placebo-controlled trial demonstrating Prostatilen reduces pain, improves urinary flow, and enhances quality of life in chronic prostatitis patients.
Key Findings
- •Dramatic pain reduction (68%)
- •Improved urinary flow
Cortexin in the Complex Treatment of Post-Stroke Epilepsy
Clinical study showing Cortexin reduces seizure frequency and improves EEG patterns in patients with post-stroke epilepsy.
Key Findings
- •Reduced seizure frequency
- •Improved EEG patterns
Efficacy of Testoluten in the Treatment of Male Infertility and Hypogonadism
Clinical evaluation of the testicular peptide Testoluten, showing improvements in sperm quality, testosterone levels, and libido in men with functional disorders.
Key Findings
- •Improved sperm parameters
- •Restored testosterone levels
Retinalamin in Diabetic Retinopathy: A Randomized Controlled Trial
Landmark RCT showing Retinalamin reduces diabetic macular edema and improves visual acuity in patients with diabetic retinopathy.
Key Findings
- •Superior visual acuity improvement
- •Greater reduction in macular edema
Immunomodulation with Thymalin Improves Outcomes in Diabetic Polyneuropathy
Study exploring the link between immune status and diabetic neuropathy, finding that Thymalin treatment reduced pain symptoms and improved nerve conduction velocity.
Key Findings
- •Significant reduction in neuropathic pain
- •Improved nerve conduction velocity
Pinealon Improves Cognitive Function and Protects Against Neurodegeneration
Multi-model study demonstrating Pinealon protects neurons, improves memory, and prevents protein aggregation in Alzheimer's disease models.
Key Findings
- •Dramatic reduction in Alzheimer's pathology
- •Improved memory and cognitive function
Bronchogen in the Complex Therapy of Chronic Obstructive Pulmonary Disease (COPD)
Clinical trial demonstrating that Bronchogen reduces the frequency of coughing fits, improves spirometry parameters, and reduces inflammation in COPD patients.
Key Findings
- •Improved lung function (FEV1)
- •Reduced respiratory symptoms
Vilon Modulates Gene Expression and Extends Lifespan in Senescence-Accelerated Mice
Groundbreaking study showing the dipeptide Vilon directly binds to DNA regulatory regions to activate immunity genes and extend lifespan by 38%.
Key Findings
- •Dramatic lifespan extension (38%)
- •Direct DNA binding demonstrated
Neuroprotective Effects of Cortexin in Traumatic Brain Injury
Clinical trial demonstrating Cortexin accelerates neurological recovery and reduces cognitive deficits following traumatic brain injury.
Key Findings
- •Accelerated neurological recovery
- •Superior cognitive outcomes
Efficacy of Retinalamin in Patients with Retinitis Pigmentosa and Diabetic Retinopathy
Research indicating that Retinalamin injections slow the progression of visual field loss in retinitis pigmentosa and improve retinal electrophysiological parameters.
Key Findings
- •Stabilization of visual field loss in 70% of patients
- •Improved retinal electrical activity (ERG)
Thymalin Restores Immune Function in Aging and Stress
Comprehensive study showing Thymalin normalizes T-cell immunity in elderly patients and accelerates recovery from immunosuppressive conditions.
Key Findings
- •Restoration of T-cell counts to normal levels
- •Enhanced NK cell cytotoxicity
Epitalon Prevents Carcinogenesis in Mice and Rats
Comprehensive carcinogenesis study showing Epitalon reduces spontaneous and chemically-induced tumors by up to 68%.
Key Findings
- •Dramatic reduction in spontaneous and induced tumors
- •Delayed tumor onset
Enhancement of Stress Resistance in Elite Rhythmic Gymnasts
Study with the Russian National Team showing improved recovery and performance using peptide bioregulators.
Key Findings
- •Reduced incidence of acute respiratory viral infections by 2.4 times
- •Accelerated recovery of muscle tissue markers
Vilon (Lys-Glu) Stimulates Immune Response in Premature Aging Models
Study demonstrating that the dipeptide Vilon stimulates proliferation of lymphocytes and cytokine production in models of immunosenescence.
Key Findings
- •Restoration of thymus function
- •Increased IL-2 production
Long-term Clinical Trial of Epithalamin and Thymalin: Effects on Mortality in Elderly
Large-scale 6-8 year longitudinal study showing 41% reduction in mortality with Epithalamin treatment in elderly patients.
Key Findings
- •41% reduction in mortality
- •Synergistic effect of pineal and thymus peptides
Epitalon Induces Reactivation of Nucleolus Organizer Regions in Elderly Lymphocytes
In vitro study showing Epitalon reactivates silenced ribosomal genes in aged lymphocytes by decondensing heterochromatin.
Key Findings
- •Reactivation of silenced ribosomal genes
- •Decondensation of chromatin
Peptide Promotes Overcoming of the Division Limit in Human Somatic Cells
Landmark in vitro study demonstrating Epitalon induces telomerase activity and overcomes the Hayflick limit.
Key Findings
- •Induction of telomerase activity in fetal fibroblast cultures
- •Elongation of telomeres by 33.3%
Peptide Geroprotector Epithalamin Increases Lifespan and Improves Immune Function in Elderly Patients
A 12-year longitudinal study demonstrating that Epithalamin administration to elderly patients reduced mortality by 28% and significantly improved immune and cardiovascular function compared to controls.
Key Findings
- •28% decrease in mortality over 12 years
- •Restoration of melatonin circadian rhythm
Peptide Epitalon Activates Telomerase Activity and Elongates Telomeres in Human Somatic Cells
A landmark in vitro study proving that the synthetic peptide Epitalon induces telomerase activity in human fibroblast cells, leading to telomere elongation and increased replicative lifespan.
Key Findings
- •Epitalon activates the telomerase enzyme
- •Telomeres elongated by 33.3%
Epitalon in the Treatment of Retinitis Pigmentosa
Clinical study showing Epitalon stabilizes or improves visual function in 90% of patients with Retinitis Pigmentosa.
Key Findings
- •Positive effect in 90% of patients
- •Improved retinal electrical activity
Geroprotective Effect of Thymalin and Epithalamin
Long-term study showing Thymalin and Epithalamin reduce morbidity and mortality in elderly people.
Key Findings
- •Significant reduction in all-cause mortality (40-50%)
- •Decreased incidence of infections and chronic diseases
Peptide Bioregulators in the Rehabilitation of Cosmonauts
Longitudinal study on cosmonauts demonstrating the efficacy of Epithalamin and Thymalin in restoring immune function and circadian rhythms.
Key Findings
- •Restoration of T-cell immunity to baseline levels within 14 days
- •Normalization of melatonin secretion profiles
Antioxidant Effects of Epithalamin and Role in Free Radical Damage
Study demonstrating Epithalamin's powerful antioxidant effects through upregulation of SOD and glutathione peroxidase.
Key Findings
- •Upregulation of SOD and Glutathione Peroxidase
- •Reduction in lipid peroxidation
Epitalon Extends Lifespan and Delays Aging in Drosophila melanogaster
Drosophila study confirming Epitalon increases lifespan by 13.6% through modulation of oxidative stress resistance.
Key Findings
- •Reproducible lifespan extension across cohorts
- •Enhanced oxidative stress resistance
Geroprotective Effect of Peptides in Gazprom Workers
Large-scale study on 11,000+ workers showing reduced mortality and morbidity.
Key Findings
- •67% reduction in overall mortality
- •Decrease in cardiovascular diseases by 44%
Pineal Peptide Preparation Epithalamin Increases the Lifespan of Fruit Flies
Study demonstrating that Epithalamin extends the lifespan of Drosophila melanogaster, confirming its evolutionary conserved mechanism.
Key Findings
- •Lifespan extension in both sexes
- •Reduced lipid peroxidation
Effect of Melatonin and Pineal Peptide Preparation Epithalamin on Lifespan
Comparative study showing that Epithalamin significantly increased the lifespan of mice and slowed down the aging of the reproductive system.
Key Findings
- •14% increase in mean lifespan
- •Delayed reproductive aging