Anti-Aging1998AnimalPineal/Aging

Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats

PMID: 9701766DOI: 10.1016/s0047-6374(98)00034-7

Anisimov V.N., Mylnikov S.V., Khavinson V.K.

N.N. Petrov Research Institute of Oncology, St. Petersburg

Mechanisms of Ageing and Development 103(2): 123-132

Study Type
Animal

Abstract

Epithalamin treatment increased the mean lifespan of female D. melanogaster, SHR mice, C3H/Sn mice and LIO rats by 11-31% (P < 0.05). Maximum lifespan rose in flies, C3H/Sn mice and rats. Mortality rate fell by 52% in flies, 52% in rats and 27% in C3H/Sn mice, and did not change in SHR mice. The authors suggest the antioxidant properties of Epithalamin explain the effect. Summary based on the PubMed abstract (PMID 9701766).

What the study did

Epithalamin treatment increased the mean lifespan of female D. melanogaster, SHR mice, C3H/Sn mice and LIO rats by 11-31% (P < 0.05). Maximum lifespan rose in flies, C3H/Sn mice and rats. Mortality rate fell by 52% in flies, 52% in rats and 27% in C3H/Sn mice, and did not change in SHR mice. The authors suggest the antioxidant properties of Epithalamin explain the effect.

Reading it honestly

This summary is based on the PubMed abstract (PMID 9701766). It describes research on the named preparation, not on any capsule product sold today, and it is not a claim that any product treats or prevents a disease.

Next stepOral bioregulator · Vita-Stream

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Study Limitations

  • •Summary based on the PubMed abstract only
  • •Single research group; independent replication is limited
  • •Results concern the studied preparation, not any capsule product

Key Findings

  • ✓Lifespan extension in three animal species
  • ✓Lower mortality rate in most models
  • ✓Antioxidant mechanism proposed

Mechanism of Action

The authors propose that antioxidant effects and increased melatonin secretion underlie the lifespan effect.