Introduction

Aging is characterized by a progressive decline in immune function and neuroendocrine regulation. The pineal gland peptide preparation, Epithalamin, has shown potent geroprotective effects in animal models. This study aimed to evaluate the long-term effects of Epithalamin on the lifespan and health markers of elderly humans.

Methodology

The study involved elderly patients aged 60-74 years. They were divided into two groups:

• Control Group: Received standard vitamin therapy.
• Treatment Group: Received Epithalamin courses (10 mg daily for 10 days) every 6 months for 3 years, followed by observation.

The observation period lasted for 12 years. Key parameters monitored included mortality rate, cardiovascular function, and immune status.

Results

Mortality Reduction

The most striking finding was the difference in mortality rates between the two groups. Over the 12-year period, the mortality rate in the Epithalamin-treated group was 28% lower than in the control group. This suggests a significant extension of lifespan.

Immune System Restoration

Patients receiving Epithalamin showed a sustained improvement in T-cell function and normalization of cytokine levels. The age-related decline in immune competence was significantly slowed.

Melatonin Levels

Epithalamin treatment restored the circadian rhythm of melatonin secretion, which typically flattens with age. This restoration is believed to be a central mechanism of the peptide's anti-aging effect.

Conclusion

Epithalamin is a highly effective geroprotector that not only extends lifespan but also improves the quality of life by maintaining immune and neuroendocrine function in the elderly.