Immunology2004

Vilon (Lys-Glu) Stimulates Immune Response in Premature Aging Models

Khavinson V.H., Kuznik B.I.

Chita Medical Academy

Context

Immunosenescence (aging of the immune system) leads to increased susceptibility to infections and cancer. Vilon is a synthetic dipeptide (Lys-Glu) designed to mimic thymic activity.

Results

Vilon was shown to bind to specific DNA sequences, promoting the expression of genes related to immune cell proliferation. In older animals, it restored the thymus structure and function to levels seen in younger animals.

Conclusion

Vilon is a potent immunomodulator with potential for treating age-related immune decline.

Key Findings

  • ✓Restoration of thymus function
  • ✓Increased IL-2 production
  • ✓Gene-specific regulation of immunity

Mechanism of Action

Vilon binds to the promoter region of interleukin-2 genes, activating their transcription.

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