Rationale

Diabetic polyneuropathy is not just metabolic but also inflammatory. Immune dysfunction plays a role in nerve damage. Thymalin, a thymus peptide, corrects immune imbalances.

Study Protocol

Diabetic patients with symptomatic polyneuropathy were treated with Thymalin (10 mg IM daily for 10 days) in addition to metabolic therapy.

Results

Pain Reduction

Patients reported a significant decrease in burning and shooting pain scores compared to the control group.

Nerve Function

Electromyography showed improved nerve conduction velocity in the peroneal and tibial nerves, suggesting remyelination or improved axonal function.

Immune Correlation

The clinical improvement correlated with the normalization of the T-helper/T-suppressor ratio, confirming the immunomodulatory mechanism of the benefit.

Conclusion

Correcting the immune deficit with Thymalin offers a novel therapeutic pathway for managing diabetic complications like neuropathy.