Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
Khavinson V.Kh., Bondarev I.E., Butyugov A.A.
St. Petersburg Institute of Bioregulation and Gerontology
Bulletin of Experimental Biology and Medicine 135(6): 590-592
Abstract
Addition of Epithalon peptide to a telomerase-negative human fetal fibroblast culture induced expression of the catalytic subunit of telomerase, telomerase enzymatic activity and telomere elongation. The authors suggest this may reflect reactivation of the telomerase gene in somatic cells. Summary based on the PubMed abstract (PMID 12937682).
Study Overview
Epitalon (Epithalon, Ala-Glu-Asp-Gly) was added to cultures of telomerase-negative human fetal fibroblasts.
Key Results
The peptide induced expression of the telomerase catalytic subunit, telomerase enzymatic activity, and telomere elongation.
Context
This is a cell-culture result from the originating research group. It does not show telomere lengthening in people, and it did not test any oral supplement. A 2004 follow-up by the same group (PMID 15455129) reported extra cell divisions in culture.
Looking for an oral pineal bioregulator?
Epithalamin and Epitalon themselves are not sold by Vita-Stream, our affiliate partner. The closest oral product it carries is Endoluten (A-8), a natural pineal-gland bioregulator. This study did not test Endoluten, so treat it as a related product, not the one studied.
Use code KymataLabs at checkout
Affiliate links: The Bioregulator Atlas earns a commission if you buy through these Vita-Stream links, at no extra cost to you. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Talk to a healthcare professional before use.
Study Limitations
- •Cell-culture study; it does not show an effect in people
- •Fetal fibroblast model
- •Single research group
Key Findings
- ✓Telomerase catalytic subunit expression induced in fetal fibroblast cultures
- ✓Telomerase activity induced
- ✓Telomere elongation in culture
Mechanism of Action
Proposed reactivation of the telomerase gene in somatic cells (authors' interpretation).