Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals
Anisimov V.N., Arutjunyan A.V., Khavinson V.K.
St. Petersburg Institute of Bioregulation and Gerontology
Neuro Endocrinology Letters 22(1): 9-18
Abstract
A review of the authors' own rodent, fly and human data. Aged rats showed age-related shifts in free-radical markers. Epithalamin lowered serum peroxide chemiluminescence 2.8-fold and diene conjugates 4.1-fold, and raised total antioxidant activity by 36.6% (p < 0.01) and SOD activity by 19.7% in males. In fruit flies it lowered peroxidation products in females and raised catalase and SOD activity. Summary based on the PubMed abstract (PMID 11335874).
What the study did
A review of the authors' own rodent, fly and human data. Aged rats showed age-related shifts in free-radical markers. Epithalamin lowered serum peroxide chemiluminescence 2.8-fold and diene conjugates 4.1-fold, and raised total antioxidant activity by 36.6% (p < 0.01) and SOD activity by 19.7% in males. In fruit flies it lowered peroxidation products in females and raised catalase and SOD activity.
Reading it honestly
This summary is based on the PubMed abstract (PMID 11335874). It describes research on the named preparation, not on any capsule product sold today, and it is not a claim that any product treats or prevents a disease.
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Epithalamin and Epitalon themselves are not sold by Vita-Stream, our affiliate partner. The closest oral product it carries is Endoluten (A-8), a natural pineal-gland bioregulator. This study did not test Endoluten, so treat it as a related product, not the one studied.
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Study Limitations
- •Summary based on the PubMed abstract only
- •Single research group; independent replication is limited
- •Results concern the studied preparation, not any capsule product
Key Findings
- ✓Age-related changes in free-radical markers
- ✓Epithalamin lowered lipid peroxidation in animals
- ✓Raised antioxidant enzyme activity
Mechanism of Action
Antioxidant effects on lipid peroxidation and antioxidant enzymes, as described by the authors.