Effect of epitalon on the lifespan increase in Drosophila melanogaster
Khavinson V.K., Izmaylov D.M., Obukhova L.K., Malinin V.V.
St. Petersburg Institute of Bioregulation and Gerontology
Mechanisms of Ageing and Development 120(1-3): 141-149
Abstract
Synthetic Epitalon (Ala-Glu-Asp-Gly) was added to the culture medium of Drosophila melanogaster (Canton-S) only from egg to larva. Adult lifespan rose by 11-16% at very low concentrations, and the increase did not depend on dose. Effective concentrations were far lower than those of melatonin. Summary based on the PubMed abstract (PMID 11087911).
What the study did
Synthetic Epitalon (Ala-Glu-Asp-Gly) was added to the culture medium of Drosophila melanogaster (Canton-S) only from egg to larva. Adult lifespan rose by 11-16% at very low concentrations, and the increase did not depend on dose. Effective concentrations were far lower than those of melatonin.
Reading it honestly
This summary is based on the PubMed abstract (PMID 11087911). It describes research on the named preparation, not on any capsule product sold today, and it is not a claim that any product treats or prevents a disease.
Looking for an oral pineal bioregulator?
Epithalamin and Epitalon themselves are not sold by Vita-Stream, our affiliate partner. The closest oral product it carries is Endoluten (A-8), a natural pineal-gland bioregulator. This study did not test Endoluten, so treat it as a related product, not the one studied.
Use code KymataLabs at checkout
Affiliate links: The Bioregulator Atlas earns a commission if you buy through these Vita-Stream links, at no extra cost to you. Dietary supplements are not intended to diagnose, treat, cure, or prevent any disease. Talk to a healthcare professional before use.
Study Limitations
- •Summary based on the PubMed abstract only
- •Single research group; independent replication is limited
- •Results concern the studied preparation, not any capsule product
Key Findings
- ✓Lifespan extension in fruit flies
- ✓Active at very low concentrations
- ✓No dose-response relationship
Mechanism of Action
Antioxidant and regulatory effects are discussed by the authors but not established.