GHK-Cu

GHK-Cu (glycyl-L-histidyl-L-lysine:copper complex) is a naturally occurring copper peptide with extensively documented roles in wound healing, tissue remodeling, and skin regeneration. Research demonstrates its activity in gene regulation related to collagen synthesis, decorin expression, antioxidant enzyme activation, and anti-inflammatory pathways. The peptide works by complexing with copper ions to modulate numerous biological processes across skin, nervous system, and vascular tissue. Preclinical studies show GHK-Cu is active at very low doses in animal models (~0.5 mcg/kg in rodents), while clinical practice employs milligram-range dosing in humans to achieve systemic effects. The peptide has shown multifunctional activity that extends beyond simple wound healing to comprehensive tissue regeneration and repair.

GHK-Cu is administered via subcutaneous injection using one of two common frequency patterns: (1) Conservative approach — 5 days per week (e.g., Monday-Friday), or (2) Alternative approach — 3 times per week (e.g., Monday, Wednesday, Friday). The typical dose range is 1–2 mg per injection. Gradual titration is recommended, starting at 1 mg and increasing to 2 mg as tolerated. Standard cycle length is 8–12 weeks, with possible extension based on individual response. The peptide can be injected at any consistent time of day. Research shows GHK-Cu supports collagen synthesis, tissue repair, and gene expression related to regenerative processes.