MOTS-c

MOTS-c (Mitochondrial ORF of the 12S rRNA Type-C) is a 16-amino-acid peptide encoded by mitochondrial DNA. Acts as metabolic regulator by activating AMPK (AMP-activated protein kinase) - key energy sensor that improves glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. Enhances insulin sensitivity, promotes fat-as-fuel, increases ATP production, and protects cells under metabolic stress (hypoxia, ischemia). Mimics physiological benefits of exercise, improves muscle endurance, and may extend lifespan (animal studies). Reduces oxidative damage. NOTE: Experimental peptide, not FDA approved.