MetabolismEnergyAnti-agingEndurance

MOTS-c

What is MOTS-c?

MOTS-c is a mitochondrial-derived peptide (MDP) that regulates metabolic homeostasis. It has been described as an "exercise mimetic" due to its ability to enhance glucose metabolism and physical performance.

Mechanism of Action

It translocates to the nucleus to regulate gene expression related to stress resistance and metabolism. It activates the folate-methionine cycle and AMPK pathway, promoting glucose uptake and fatty acid oxidation.

Benefits

  • Enhances insulin sensitivity
  • Promotes weight loss
  • Increases physical endurance
  • Mitochondrial biogenesis
  • Anti-aging metabolic effects

Typical Dosage

  • 200mcg-1000mcg (1mg) daily, gradually titrated
  • Typical: 5-15mg per week
  • Split: 2-5mg subcutaneous, 2-3x weekly
  • 8-16 week cycles
  • Abdominal subcutaneous injection

Side Effects

  • Injection site pain (common)
  • Potential for hypoglycemia
  • Nausea

Negative Interactions

  • No established human contraindications (experimental)
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