AppetiteFat LossMetabolism

Retatrutide

What is Retatrutide?

Retatrutide is a triple agonist (GLP-1, GIP, and Glucagon) known as the "King" of metabolic peptides. It engages three distinct receptor pathways for maximum fat burning and metabolic control.

Mechanism of Action

Activates GLP-1 (appetite), GIP (metabolism/insulin), and Glucagon (energy expenditure/liver fat). The addition of Glucagon agonism significantly increases resting energy expenditure.

Benefits

  • Highest potency for weight loss
  • Increases resting energy expenditure
  • Rapid reduction in liver fat
  • Improved lipid profile

Typical Dosage

  • 2mg once weekly
  • 4mg once weekly
  • 8mg once weekly
  • 12mg once weekly

Side Effects

  • Increased heart rate
  • Nausea
  • Skin sensitivity (Allodynia)
  • Appetite suppression

Negative Interactions

  • Alcohol
  • High-fat meals
  • Other GLP-1 medications
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