Metabolic•FDA Approved

Tesamorelin

Tesamorelin is a potent synthetic GHRH analogue, most famous for its FDA approval to treat HIV-associated lipodystrophy (excess abdominal fat). It is considered the strongest GHRH peptide for visceral fat reduction.

Mechanism of Action

It binds to GHRH receptors with high affinity and stability due to its N-terminal modification (trans-3-hexenoic acid). It potently stimulates pulsatile GH release, leading to significant reductions in visceral adipose tissue (VAT).

Key Benefits

Significant reduction in visceral belly fat
Increases IGF-1 levels
Improves lipid profile (cholesterol/triglycerides)
Enhances cognition in some studies
Muscle toning

Research Protocol

Maintenance
1mg-2mg daily
FDA approved dose is 2mg daily. Research protocols often use 1mg. Best taken in the morning or before bed.

Chemical Properties

FormulaC221H366N72O67S
Mol. Weight5135.9 g/mol

Side Effects & Risks

  • •Injection site reactions
  • •Arthralgia (joint pain)
  • •Potential insulin resistance (monitor blood glucose)
  • •Fluid retention

Amino Acid Sequence

Trans-3-hexenoic acid-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Asp-Ile-Lys-Asn-His-Arg-Gly-Gln-Glu-Ser-Asn-Gln-Glu-Gln-Glu-Gln-Gln-Asn-Ser-Phe-Leu-Ala-Gly-Gln-Asp-Arg
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