Western Peptide Index
Deep dives into the science, mechanisms, and protocols of modern synthetic peptides.
5-Amino-1MQ
5-Amino-1MQ is a small molecule inhibitor of the enzyme NNMT (Nicotinamide N-methyltransferase). By blocking NNMT, it increases NAD+ levels and metabolic rate, making it a potent agent for fat loss and longevity.
AOD-9604
AOD-9604 (Anti-Obesity Drug) is a modified fragment of human growth hormone (residues 177-191). It was developed to mimic the fat-burning properties of HGH without the growth-promoting or insulin-resistance effects.
BPC-157
Body Protection Compound-157 (BPC-157) is a pentadecapeptide derived from a protective protein found in human gastric juice. It is renowned for its systemic healing properties, particularly in tendons, ligaments, and the gastrointestinal tract.
CJC-1295 (No DAC)
CJC-1295 (No DAC), also known as Modified GRF 1-29, is a synthetic analogue of Growth Hormone Releasing Hormone (GHRH). It is designed to stimulate the release of growth hormone from the pituitary gland in a pulsatile manner, mimicking the body's natural rhythm.
Epitalon
Epitalon (Epithalon) is a synthetic tetrapeptide derived from the pineal gland. It is considered one of the most potent anti-aging peptides due to its ability to activate telomerase and lengthen telomeres.
GHK-Cu
GHK-Cu is a naturally occurring copper complex that was first identified in human plasma. It has powerful regenerative properties, particularly for skin and hair health.
Ipamorelin
Ipamorelin is a selective Growth Hormone Secretagogue (GHS) and ghrelin receptor agonist. It is known for being one of the cleanest and most versatile GH peptides, stimulating release without significantly increasing cortisol or prolactin.
Melanotan 1
Melanotan 1 (Afamelanotide) is a synthetic analogue of alpha-MSH, similar to Melanotan 2 but with a much higher selectivity for the MC1 receptor. It promotes tanning with significantly fewer side effects.
Melanotan 2
Melanotan 2 (MT2) is a synthetic analogue of alpha-melanocyte stimulating hormone (α-MSH). It is widely used for its ability to stimulate melanogenesis (tanning) and enhance libido.
MK-677 (Ibutamoren)
MK-677 is a non-peptide, orally active growth hormone secretagogue. Unlike injectable peptides, it is a small molecule that mimics ghrelin and provides sustained elevations in GH and IGF-1 levels for 24 hours.
MOTS-c
MOTS-c is a mitochondrial-derived peptide (MDP) that regulates metabolic homeostasis. It has been described as an "exercise mimetic" due to its ability to enhance glucose metabolism and physical performance.
PT-141 (Bremelanotide)
PT-141 is a metabolite of Melanotan 2 that was developed specifically to treat sexual dysfunction. It is FDA approved for hypoactive sexual desire disorder in women and is effective for ED in men.
Retatrutide
Retatrutide is a triple agonist (GLP-1, GIP, and Glucagon) known as the "King" of metabolic peptides. It engages three distinct receptor pathways for maximum fat burning and metabolic control.
Selank
Selank is a synthetic heptapeptide analogue of the endogenous peptide Tuftsin. It is primarily an anxiolytic (anti-anxiety) agent with nootropic and antiviral properties.
Semaglutide
Semaglutide is a GLP-1 receptor agonist that mimics the action of the human glucagon-like peptide-1 (GLP-1). It increases insulin secretion, decreases glucagon secretion, and slows gastric emptying.
Semax
Semax is a synthetic heptapeptide analogue of ACTH(4-10). Developed in Russia, it is widely used for its neuroprotective and cognitive-enhancing properties, particularly after stroke or for ADHD.
Sermorelin
Sermorelin is a synthetic version of the first 29 amino acids of human GHRH. It has a long history of safe use for diagnosing and treating growth hormone deficiency and is a popular anti-aging peptide.
SLU-pp-332
SLU-pp-332 is a novel synthetic "exercise mimetic" that boosts mitochondrial function and endurance without physical exertion. It directly activates estrogen-related receptors (ERRs), mimicking the metabolic effects of exercise.
SS-31 (Elamipretide)
SS-31, also known as Elamipretide, is a mitochondria-targeted tetrapeptide. It penetrates the cell membrane and concentrates in the inner mitochondrial membrane, where it restores bioenergetics and reduces oxidative stress.
TB-500
TB-500 is a synthetic fraction of the protein thymosin beta-4, which is present in virtually all human and animal cells. It plays a vital role in building new blood vessels, small muscle tissue fibers, and cell migration.
Tesamorelin
Tesamorelin is a potent synthetic GHRH analogue, most famous for its FDA approval to treat HIV-associated lipodystrophy (excess abdominal fat). It is considered the strongest GHRH peptide for visceral fat reduction.
Thymosin Alpha-1
Thymosin Alpha-1 (Ta1) is a peptide originally isolated from the thymus gland. It is a potent immune modulator used to boost the immune system in fighting chronic viral infections, cancer, and autoimmune conditions.
Tirzepatide
Tirzepatide is a dual GIP and GLP-1 receptor agonist. It is the first "twincretin" medication, offering superior weight loss and glycemic control compared to GLP-1 mono-agonists.