Libido

PT-141

What is PT-141?

PT-141 is a metabolite of Melanotan 2 that was developed specifically to treat sexual dysfunction. It is FDA approved for hypoactive sexual desire disorder in women and is effective for ED in men.

Mechanism of Action

It acts as a selective agonist of melanocortin receptors MC3R and MC4R in the central nervous system. Unlike Viagra (which is vascular), PT-141 works on the neurological pathway of arousal.

Benefits

  • Treats erectile dysfunction (non-vascular mechanism)
  • Increases libido and sexual desire in women
  • Does not affect blood pressure as much as MT2
  • No tanning effect

Typical Dosage

  • 1-2mg subcutaneously (as needed)
  • Administer 45 mins before activity

Side Effects

  • Nausea
  • Flushing
  • Headache
  • Injection site reaction

Dosage Protocol

Administer 1–2 mg subcutaneously approximately 45 minutes to 1 hour before anticipated sexual activity. Start with a lower dose (1 mg) to assess tolerance, as nausea is a common side effect. Do not exceed one dose per 24 hours or 8 doses per month. Effects can last up to 24 hours.

Reconstitution

Add 1.0 mL bacteriostatic water to 10 mg vial → 10 mg/mL. 1 mg = 0.1 mL (10 units). Or add 2.0 mL for 5 mg/mL (1 mg = 0.2 mL).

Dosing Schedule

Standard Protocol

  • •As Needed: 1-2 mg
  • •Timing: 45-60 mins before activity
  • •Limit: Max 1 dose/day, 8 doses/month

Negative Interactions

  • Uncontrolled hypertension
  • Cardiovascular disease
  • Naltrexone (may block effects)
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