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Ipamorelin

What is Ipamorelin?

Ipamorelin is a selective Growth Hormone Secretagogue (GHS) and ghrelin receptor agonist. It is known for being one of the cleanest and most versatile GH peptides, stimulating release without significantly increasing cortisol or prolactin.

Mechanism of Action

Ipamorelin mimics ghrelin and binds to the GHS receptor (GHS-R1a) in the pituitary, triggering a strong release of growth hormone. Unlike other secretagogues, it is highly selective and does not stimulate ACTH (cortisol) or prolactin release.

Benefits

  • Increases natural growth hormone production
  • Improves sleep depth and quality
  • Promotes fat loss and muscle retention
  • Strengthens connective tissue
  • No significant hunger increase (unlike MK-677)

Typical Dosage

  • 200mcg daily
  • 300mcg 5x weekly

Side Effects

  • Mild headache
  • Injection site redness
  • Rare dizziness

Dosage Protocol

Ipamorelin is administered once daily via subcutaneous injection, ideally 30–60 minutes before bedtime on an empty stomach to synergize with natural nocturnal GH secretion. The educational dose range is 100–300 mcg per day with gradual titration recommended. Start at 100 mcg daily and increase by ~50 mcg every 1–2 weeks as tolerated. Target dose is typically 200–250 mcg daily by Weeks 5–12. Standard cycle length is 8–12 weeks, with optional extension to 16 weeks, followed by a 2–4 week off-cycle to resensitize receptors. Ipamorelin has a short half-life (~1.5–2.5 hours), making consistent daily timing important for optimal effects.

Reconstitution

Add 3.0 mL bacteriostatic water to the 10 mg vial to achieve approximately 3.33 mg/mL concentration. Draw water slowly and inject down the vial wall to avoid foaming. Gently swirl or roll until dissolved—do not shake vigorously. Label the vial and refrigerate at 2–8°C, protected from light.

Dosing Schedule

Standard Protocol

  • •Weeks 1-2: 100 mcg once daily before bed (≈3 units)
  • •Weeks 3-4: 150 mcg once daily before bed (≈5 units)
  • •Weeks 5-8: 200 mcg once daily before bed (≈6 units)
  • •Weeks 9-12: 250 mcg once daily before bed (≈8 units)
  • •Optional extension: Continue at 250 mcg daily for Weeks 13-16
  • •Off-cycle: Take 2-4 weeks off to resensitize receptors

Negative Interactions

  • Food
  • Insulin
  • Alcohol

This information is for educational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional before starting any peptide protocol. Inject on an empty stomach (avoid food 2–3 hours before and 30–60 minutes after) to optimize GH release.

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