Ipamorelin

Ipamorelin is a selective growth hormone secretagogue and ghrelin mimetic that stimulates the natural release of growth hormone from the pituitary gland. Unlike other growth hormone peptides, Ipamorelin is highly selective and doesn't significantly increase cortisol, prolactin, or other hormones, resulting in fewer side effects. It works by binding to the ghrelin receptor (GHSR) in the pituitary, triggering a cascade that leads to GH release. Benefits include improved body composition with increased lean muscle mass and reduced body fat, enhanced recovery from exercise and injury, better sleep quality, and potential anti-aging effects. Ipamorelin is often combined with CJC-1295 for synergistic effects on GH release patterns.

Ipamorelin is administered once daily via subcutaneous injection, ideally 30–60 minutes before bedtime on an empty stomach to synergize with natural nocturnal GH secretion. The educational dose range is 100–300 mcg per day with gradual titration recommended. Start at 100 mcg daily and increase by ~50 mcg every 1–2 weeks as tolerated. Target dose is typically 200–250 mcg daily by Weeks 5–12. Standard cycle length is 8–12 weeks, with optional extension to 16 weeks, followed by a 2–4 week off-cycle to resensitize receptors. Ipamorelin has a short half-life (~1.5–2.5 hours), making consistent daily timing important for optimal effects.