Exercise MimeticMetabolismEnduranceMitochondrialFat Loss

SLU-PP-332

What is SLU-PP-332?

SLU-pp-332 is a novel synthetic "exercise mimetic" that boosts mitochondrial function and endurance without physical exertion. It directly activates estrogen-related receptors (ERRs), mimicking the metabolic effects of exercise.

Mechanism of Action

It acts as a potent agonist for Estrogen-Related Receptors (ERRα, ERRβ, ERRγ). This activation triggers the transcription of genes involved in mitochondrial biogenesis, fatty acid oxidation, and glucose metabolism, effectively simulating the cellular response to aerobic exercise.

Benefits

  • Mimics the effects of aerobic exercise
  • Increases mitochondrial density and function
  • Enhances endurance and VO2 max
  • Promotes fat loss and metabolic health
  • Preserves muscle mass during weight loss

Typical Dosage

  • Research protocol: 1250mcg-2500mcg daily (based on animal studies)
  • Suggested: 200-800mcg daily in 2-3 doses
  • Advanced: 0.25mg-1.5mg 1-3x daily

Side Effects

  • Long-term safety in humans unknown
  • Potential mild gastrointestinal discomfort
  • Possible sleep disturbance if taken late

Negative Interactions

  • No established human contraindications (preclinical only)
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