The Science ofRadical Longevity
From pineal restoration to senolytic clearance. A comprehensive, tiered strategy to target the nine hallmarks of aging.
Executive Summary
Aging is not a single process but a cascade of failures: accumulation of senescent cells, mitochondrial dysfunction, and neuroendocrine decline. This protocol attacks these vectors in three tiers, starting with Khavinson's foundational regulation and ending with experimental gene modulation.
⏳ Telomere Elongation
Restoring the Hayflick Limit via Epitalon/Endoluten
🗑️ Senolysis
Clearing "Zombie Cells" via FOXO4-DRI
The "Protector 3": The Golden Triangle
Goal: Neuroendocrine & Immune Homeostasis
Known as the "Golden Triangle" of longevity, this combination addresses the three most critical systems for aging: the Neuroendocrine system, the Immune system, and the Hematopoietic system.
Protector 3 Plus
Gold Standard StackThe definitive longevity stack in a convenient 3-in-1 format.
- Endoluten (Pineal): The "Commander". Up-regulates melatonin, cortisol rhythm, and reproductive health.
- Vladonix (Thymus): Reverses thymic involution, restoring T-cell production.
- Bonemarrow (Bonomarlot): Supports red/white blood cell generation (hematopoiesis).
Neuro-Immuno-Endocrine
Genomic & Mitochondrial Potentiation
Goal: DNA Repair & Metabolic Efficiency
Epitalon (Synthetic)
Telomerase ActivatorThe synthetic version of Endoluten. Induces telomerase activity to lengthen telomeres, acting as a "reset button" for cellular replication limits.
Epitalon Spray
Needle-FreeA high-dose intranasal or sublingual option for those avoiding injections.
GHK-Cu (The Copper Peptide)
Gene ModulatorResets 30% of human genes to a younger expression state. Potent effects on collagen synthesis, varying wound healing, and DNA repair.
The "Time Dilation" Stack
Goal: Senolysis & mTOR Inhibition (Experimental)
⚠️ ADVANCED RESEARCH ONLY
These compounds modulate fundamental cell survival pathways (p53, mTOR). Incorrect use can have serious consequences. Consult a longevity physician.
FOXO4-DRI
SenolyticA peptide that forces "Zombie Cells" (senescent cells) to undergo apoptosis by interfering with the FOXO4-p53 interaction.
- • Mechanism: p53-mediated apoptosis
- • Target: Senescent cells (SASPs)
- • Status: Experimental
MOTS-c
Mitochondrial DerivedEncodes directly from mitochondrial DNA. Acts as an "exercise mimetic" enhancing insulin sensitivity and preventing obesity/metabolic decline.
- • Mechanism: Folate cycle / AMPK Activation
- • Effect: Metabolic flexibility
Honorable Mention: Rapamycin (Sirolimus)
The most robust pharmacological life-extender known. Inhibits mTORC1 to mimic calorie restriction.