Architecting theApex Cognitive State
A tiered, multi-vector approach to neuroplasticity, memory retention, and executive function. From foundational bioregulators to experimental hyperplasticity agents.
Executive Summary
True cognitive enhancement requires addressing the brain's biological hierarchy: vascular supply, metabolic waste clearance, and synaptic density. This protocol is structured in three tiers, allowing users to scale their intervention from maintenance (Tier 1) to aggressive neurogenesis (Tier 3).
⚡ Accelerated Learning
Enhanced long-term potentiation (LTP) via BDNF modulation
🛡️ Neuroprotection
Resistance to oxidative stress & glutamate excitotoxicity
The Biological Foundation
Goal: Restore Homeostasis & Metabolic Support
Before attempting to supercharge neural firing, one must ensure the hardware is maintained. The core of Khavinson's research for cognitive decline lies in the triad of brain tissue, vascular supply, and liver metabolism.
Neuro 3 Plus - The "Maintenance Triad"
Highly Recommended BaseCombines three critical bioregulators in a single capsule for systemic cognitive support.
- Cerluten (Brain): Enhances neuronal function and memory.
- Ventfort (Vessels): Improves cerebral blood flow and oxygen delivery.
- Svetinorm (Liver): Optimizes detoxification for clearer cognition.
Synergistic Triad
Targeted Potentiation
Goal: Upregulate Neurotrophic Factors (BDNF/NGF)
Semax & Selank
Synthetic PeptideThe Russian gold standard. Semax sharply increases BDNF (Brain-Derived Neurotrophic Factor), while Selank modulates GABA/Enkephalins for "calm focus".
Cognizin® (Citicoline)
Bioavailable CholineA patented, clinically tested form of Citicoline. It provides essential brain fuel by supporting Acetylcholine synthesis (focus) and Phosphatidylcholine (membrane structure).
Polygala Tenuifolia 20:1
Novel Mechanism"The Will Strengthener". Unique triple-action mechanism: NMDA antagonism (neuroprotection), Triple Reuptake Inhibition (Mood/Focus), and potent BDNF expression.
The "Hyperplasticity" Stack
Goal: Aggressive Synaptogenesis (Experimental)
⚠️ ADVANCED USERS ONLY
The compounds in Tier 3 (Dihexa, 4-DMA-7,8-DHF) are potent growth factor mimetics. While promising for repairing damage, theoretical risks exist regarding uncontrolled cell proliferation. Consult a physician.
Dihexa
HGF MimeticDeveloped by Washington State University. A hepatocyte growth factor (c-Met) activator reported to be 7 orders of magnitude more potent than BDNF at creating new synapses.
- • Mechanism: c-Met Dimerization
- • Effect: Rapid dendritic arborization
- • Status: Pre-clinical
4-DMA-7,8-DHF
TrkB AgonistA synthetic derivative of 7,8-Dihydroxyflavone with superior bioavailability and longer half-life. It directly mimics BDNF at the TrkB receptor.
- • vs. 7,8-DHF: Longer duration (8-16hr brain activity)
- • Effect: Potent LTP enhancement
- • Synergy: Stacks with Polygala for dual-pathway support
Putting It All Together: The Weekly Schedule
Discontinue stimulants and synthetic peptides (Semax/4-DMA). Continue Polygala and Neuro 3 Plus to maintain baseline neurotrophic support and allow receptor re-sensitization.