Science
5-Amino-1MQ: The "Anti-Obesity" Molecule
It is not a stimulant. It is not an an appetite suppressant. 5-Amino-1MQ works by blocking the enzyme that makes fat cells grow.
ByPeptide Bioregulator Atlas (Adapted)
April 9, 2024
Table of Contents
What is 5-Amino-1MQ?
5-Amino-1MQ is a small, membrane-permeable molecule that functions as a specific inhibitor of the Nicotinamide N-Methyltransferase (NNMT) enzyme. Unlike traditional stimulants that burn fat by revving up your heart rate (and anxiety), 5-Amino-1MQ works by correcting a fundamental metabolic inefficiency in fat cells.
Mechanism of Action: Fixing the NAD+ Cycle
The enzyme NNMT acts as a "sink" for NAD+ in adipose (fat) tissue. High levels of NNMT are associated with obesity and type 2 diabetes.
- NNMT Inhibition: By blocking this enzyme, 5-Amino-1MQ prevents the waste of NAD+.
- NAD+ Sparing: This leads to a significant increase in intracellular NAD+ levels.
- Metabolic Rate: Higher NAD+ activates Sirtuins (SIRT1), which act as metabolic master regulators. The result is increased Basal Metabolic Rate (BMR)—your body burns more calories just existing.
Research Benefits
- Fat Loss: Promoted reversal of diet-induced obesity in mice without changes in food intake.
- Muscle Sparing: Unlike calorie restriction which eats muscle, the NAD+ boost supports muscle satellite cells. It is successfully used to treat sarcopenia (muscle wasting) in elderly models.
- Energy: Users report clean, non-jittery energy due to improved mitochondrial efficiency.
Usage & Protocol
- Administration: It is orally bioavailable. No needles required.
- ** Dose:** Standard protocol is ** 50mg to 150mg ** per day(Capsules).
- ** Timing:** Taken with a meal(fat enhances absorption).
- ** Cycle:** Typically run for 8 - 12 weeks.